http://purl.uniprot.org/citations/21303547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21303547 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundA strong association between stress resistance and longevity in multicellular organisms has been established as many mutations that extend lifespan also show increased resistance to stress. AAK-2, the C. elegans homolog of an alpha subunit of AMP-activated protein kinase (AMPK) is an intracellular fuel sensor that regulates cellular energy homeostasis and functions in stress resistance and lifespan extension.FindingsHere, we investigated global transcriptional responses of aak-2 mutants to oxidative stress and in turn identified potential downstream targets of AAK-2 involved in stress resistance in C. elegans. We employed massively parallel Illumina sequencing technology and performed comprehensive comparative transcriptome analysis. Specifically, we compared the transcriptomes of aak-2 and wild type animals under normal conditions and conditions of induced oxidative stress. This research has presented a snapshot of genome-wide transcriptional activities that take place in C. elegans in response to oxidative stress both in the presence and absence of AAK-2.ConclusionsThe analysis presented in this study has enabled us to identify potential genes involved in stress resistance that may be either directly or indirectly under the control of AAK-2. Furthermore, we have extended our current knowledge of general defense responses of C. elegans against oxidative stress supporting the function for AAK-2 in inhibition of biosynthetic processes, especially lipid synthesis, under oxidative stress and transcriptional regulation of genes involved in reproductive processes."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.org/dc/terms/identifier | "doi:10.1186/1756-0500-4-34"xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/author | "Baillie D.L."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/author | "Jones S.J."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/author | "Shin H."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/author | "Koo H.S."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/author | "Fejes A.P."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/name | "BMC Res Notes"xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/pages | "34"xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/title | "Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing."xsd:string |
http://purl.uniprot.org/citations/21303547 | http://purl.uniprot.org/core/volume | "4"xsd:string |
http://purl.uniprot.org/citations/21303547 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21303547 |
http://purl.uniprot.org/citations/21303547 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21303547 |
http://purl.uniprot.org/uniprot/#_Q17693-mappedCitation-21303547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303547 |
http://purl.uniprot.org/uniprot/Q17693 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21303547 |