| http://purl.uniprot.org/citations/21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21303971 | http://www.w3.org/2000/01/rdf-schema#comment | "Increased β-catenin transcriptional activity downstream of the Wnt/Wingless signaling pathway has been observed in many human tumors, most notably colorectal carcinomas. However, β-catenin activation is also observed in many human malignancies with no observable Wnt activity. Wnt-independent pathways that activate β-catenin remain undefined, yet have the potential to play a significant role during tumorigenesis. Here, we report that phosphotidylinositol phosphate kinase Iγ (PIPKIγ), an enzyme that generates phosphoinositide messengers in vivo, directly associates with β-catenin and increases β-catenin activity downstream of growth factor stimulation. PIPKIγ expression and kinase activity enhance β-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. Lastly, we show that β-catenin is required for PIPKIγ-dependent increased cell proliferation. These results reveal a novel mechanism in which PIPKIγ expression and catalytic activity enhance β-catenin nuclear translocation and expression of its target genes to promote tumorigenic phenotypes."xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-2480"xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/author | "Anderson R."xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/author | "Schramp M."xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/author | "Thapa N."xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/author | "Heck J."xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/pages | "1282-1291"xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/title | "PIPKIgamma regulates beta-catenin transcriptional activity downstream of growth factor receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/21303971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21303971 |
| http://purl.uniprot.org/citations/21303971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21303971 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_B2ZRE2-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_B2ZRG2-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_B4DGU4-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_B4DL06-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_B4DVZ9-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_B5BU28-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_G9GAG7-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_O60331-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_P35222-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |
| http://purl.uniprot.org/uniprot/#_Q7LE22-mappedCitation-21303971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21303971 |