| http://purl.uniprot.org/citations/21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21304511 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hedgehog (Hh) morphogen directs distinct cell responses according to its distinct signalling levels. Hh signalling stabilizes transcription factor cubitus interruptus (Ci) by prohibiting SCF(Slimb)-dependent ubiquitylation and proteolysis of Ci. How graded Hh signalling confers differential SCF(Slimb)-mediated Ci proteolysis in responding cells remains unclear. Here, we show that in COP9 signalosome (CSN) mutants, in which deneddylation of SCF(Slimb) is inactivated, Ci is destabilized in low-to-intermediate Hh signalling cells. As a consequence, expression of the low-threshold Hh target gene dpp is disrupted, highlighting the critical role of CSN deneddylation on low-to-intermediate Hh signalling response. The status of Ci phosphorylation and the level of E1 ubiquitin-activating enzyme are tightly coupled to this CSN regulation. We propose that the affinity of substrate-E3 interaction, ligase activity and E1 activity are three major determinants for substrate ubiquitylation and thereby substrate degradation in vivo."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms1185"xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Huang Y.C."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Ho M.S."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Chen W.Y."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Chien C.T."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Wu J.T."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Lin W.H."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Tang C.Y."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/author | "Pi H."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/pages | "182"xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/title | "CSN-mediated deneddylation differentially modulates Ci(155) proteolysis to promote Hedgehog signalling responses."xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/21304511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21304511 |
| http://purl.uniprot.org/citations/21304511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21304511 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHK1-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHM2-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHX3-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KF46-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |
| http://purl.uniprot.org/uniprot/#_E1JH01-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |
| http://purl.uniprot.org/uniprot/#_H9XVL6-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |
| http://purl.uniprot.org/uniprot/#_H9XVL7-mappedCitation-21304511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21304511 |