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http://purl.uniprot.org/citations/21308731 | http://www.w3.org/2000/01/rdf-schema#comment | "SPARC (osteonectin/BM-40), a secreted matricellular protein that promotes cellular deadhesion and motility in wound healing, carcinogenesis, and inflammation, binds to the scavenger receptor stabilin-1 in alternatively activated macrophages and undergoes endocytosis and clearance from the extracellular space. Both SPARC and stabilin-1 are expressed by endothelial cells during inflammation, but their interaction in this context is unknown. We have identified a binding site on SPARC for stabilin-1 by a solid-state peptide array coupled with a modified enzyme-linked immunosorbent assay. A monoclonal antibody that recognizes the identified binding site was also characterized that could be an inhibitor for the SPARC-stabilin-1 interaction in macrophages or endothelial cells."xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.23015"xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/author | "Sage E.H."xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/author | "Workman G."xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/pages | "1003-1008"xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/title | "Identification of a sequence in the matricellular protein SPARC that interacts with the scavenger receptor stabilin-1."xsd:string |
http://purl.uniprot.org/citations/21308731 | http://purl.uniprot.org/core/volume | "112"xsd:string |
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