| http://purl.uniprot.org/citations/21308776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21308776 | http://www.w3.org/2000/01/rdf-schema#comment | "Delta-like 1/fetal antigen 1 (DLK1/FA-1) is a transmembrane protein belonging to the Notch/Delta family that acts as a membrane-associated or a soluble protein to regulate regeneration of a number of adult tissues. Here we examined the role of DLK1/FA-1 in bone biology using osteoblast-specific Dlk1-overexpressing mice (Col1-Dlk1). Col1-Dlk1 mice displayed growth retardation and significantly reduced total body weight and bone mineral density (BMD). Micro-computed tomographis (µCT) scanning revealed a reduced trabecular and cortical bone volume fraction. Tissue-level histomorphometric analysis demonstrated decreased bone-formation rate and enhanced bone resorption in Col1-Dlk1 mice compared with wild-type mice. At a cellular level, Dlk1 markedly reduced the total number of bone marrow (BM)-derived colony-forming units fibroblasts (CFU-Fs), as well as their osteogenic capacity. In a number of in vitro culture systems, Dlk1 stimulated osteoclastogenesis indirectly through osteoblast-dependent increased production of proinflammatory bone-resorbing cytokines (eg, Il7, Tnfa, and Ccl3). We found that ovariectomy (ovx)-induced bone loss was associated with increased production of Dlk1 in the bone marrow by activated T cells. Interestingly, Dlk1(-/-) mice were significantly protected from ovx-induced bone loss compared with wild-type mice. Thus we identified Dlk1 as a novel regulator of bone mass that functions to inhibit bone formation and to stimulate bone resorption. Increasing DLK1 production by T cells under estrogen deficiency suggests its possible use as a therapeutic target for preventing postmenopausal bone loss."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.346"xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Kassem M."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Abdallah B.M."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Ruiz-Hidalgo M.J."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Mahmood A."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Amling M."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Laborda J."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Ditzel N."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Schilling A.F."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Isa A."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/author | "Traustadottir G.A."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/pages | "1457-1471"xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/title | "DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice."xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/21308776 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21308776 |
| http://purl.uniprot.org/citations/21308776 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21308776 |
| http://purl.uniprot.org/uniprot/Q09163#attribution-709B4600E87925ED8E54E85BB8D17BD2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21308776 |
| http://purl.uniprot.org/uniprot/Q09163#attribution-CED8B7289E46BF07B6963ECDFCCB7CEC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21308776 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWE0-mappedCitation-21308776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21308776 |
| http://purl.uniprot.org/uniprot/#_A0A087WPY2-mappedCitation-21308776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21308776 |
| http://purl.uniprot.org/uniprot/#_A0A087WQQ4-mappedCitation-21308776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21308776 |