| http://purl.uniprot.org/citations/21310825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21310825 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies indicate that androgen receptor (AR) signaling is critical for prostate cancer cell survival, even in castration-resistant disease wherein AR continues to function independently of exogenous androgens. Integrin-mediated adhesion to the extracellular matrix is also important for prostate cell survival. AR-positive prostate cancer cells express primarily integrin α6β1 and adhere to a laminin-rich matrix. In this study, we show that active nuclear-localized AR protects prostate cancer cells from death induced by phosphoinositide 3-kinase (PI3K) inhibition when cells adhere to laminin. Resistance to PI3K inhibition is mediated directly by an AR-dependent increase in integrin α6β1 mRNA transcription and protein expression. Subsequent signaling by integrin α6β1 in AR-expressing cells increased NF-κB activation and Bcl-xL expression. Blocking AR, integrin α6, NF-κB, or Bcl-xL concurrent with inhibition of PI3K was sufficient and necessary to trigger death of laminin-adherent AR-expressing cells. Taken together, these results define a novel integrin-dependent survival pathway in prostate cancer cells that is regulated by AR, independent of and parallel to the PI3K pathway. Our findings suggest that combined targeting of both the AR/α6β1 and PI3K pathways may effectively trigger prostate cancer cell death, enhancing the potential therapeutic value of PI3K inhibitors being evaluated in this setting."xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-2745"xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/author | "Miranti C.K."xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/author | "Lamb L.E."xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/author | "Zarif J.C."xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/pages | "2739-2749"xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/title | "The androgen receptor induces integrin alpha6beta1 to promote prostate tumor cell survival via NF-kappaB and Bcl-xL Independently of PI3K signaling."xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/21310825 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21310825 |
| http://purl.uniprot.org/citations/21310825 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21310825 |
| http://purl.uniprot.org/uniprot/P10275#attribution-01A14A700606835E004B4AB75F56B1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/P10275#attribution-0626349DDA779A6B2B23071FD12034A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/P26006#attribution-0626349DDA779A6B2B23071FD12034A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/P23229#attribution-01A14A700606835E004B4AB75F56B1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/P23229#attribution-0626349DDA779A6B2B23071FD12034A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/P17301#attribution-0626349DDA779A6B2B23071FD12034A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/P06756#attribution-0626349DDA779A6B2B23071FD12034A7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |
| http://purl.uniprot.org/uniprot/Q04206#attribution-01A14A700606835E004B4AB75F56B1E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21310825 |