| http://purl.uniprot.org/citations/21311773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21311773 | http://www.w3.org/2000/01/rdf-schema#comment | "The aspartic protease cathepsin-D (cath-D) is overexpressed by human epithelial breast cancer cells and is closely correlated with poor prognosis in breast cancer. The adipocyte is one of the most prominent cell types in the tumor-microenvironment of breast cancer, and clinical studies have shown that obesity increases the incidence of breast cancer. Here, we provide the first evidence that cath-D expression is up-regulated in adipose tissue from obese human beings, as well as in adipocytes from the obese C57BI6/J mouse. Cath-D expression is also increased during human and mouse adipocyte differentiation. We show that cath-D silencing in 3T3-F442A murine preadipocytes leads to lipid-depleted cells after adipogenesis induction, and inhibits of the expression of PPARγ, HSL and aP2 adipocyte differentiation markers. Altogether, our findings demonstrate the key role of cath-D in the control of adipogenesis, and suggest that cath-D may be a novel target in obesity."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0016452"xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Muller C."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Daviaud D."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Valet P."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Quilliot D."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Derocq D."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Liaudet-Coopman E."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Prebois C."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Dray C."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Masson O."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/author | "Meulle A."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/pages | "e16452"xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/title | "Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis."xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21311773 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21311773 |
| http://purl.uniprot.org/citations/21311773 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21311773 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3L4-mappedCitation-21311773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21311773 |
| http://purl.uniprot.org/uniprot/#_Q3TWR6-mappedCitation-21311773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21311773 |
| http://purl.uniprot.org/uniprot/#_Q3TXL5-mappedCitation-21311773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21311773 |
| http://purl.uniprot.org/uniprot/#_Q05BF3-mappedCitation-21311773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21311773 |
| http://purl.uniprot.org/uniprot/#_Q3U8W5-mappedCitation-21311773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21311773 |