| http://purl.uniprot.org/citations/21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21315262 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypothalamic neuropeptides play essential roles in regulating energy and body weight balance. Energy imbalance and obesity have been linked to hypothalamic signaling defects in regulating neuropeptide genes; however, it is unknown whether dysregulation of neuropeptide exocytosis could be critically involved. This study discovered that synaptotagmin-4, an atypical modulator of synaptic exocytosis, is expressed most abundantly in oxytocin neurons of the hypothalamus. Synaptotagmin-4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of synaptotagmin-4 and thus enhanced negative regulation of oxytocin release. Overexpressing synaptotagmin-4 in hypothalamic oxytocin neurons and centrally antagonizing oxytocin in mice are similarly obesogenic. Synaptotagmin-4 inhibition prevents against dietary obesity by normalizing oxytocin release and energy balance under chronic nutritional excess. In conclusion, the negative regulation of synaptotagmin-4 on oxytocin release represents a hypothalamic basis of neuropeptide exocytosis in controlling obesity and related diseases."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.12.036"xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Bai H."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Dean C."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Zhang G."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Wu Q."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Meng Q."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Cai D."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/author | "Guariglia S."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/pages | "523-535"xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/title | "Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance."xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/21315262 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21315262 |
| http://purl.uniprot.org/citations/21315262 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21315262 |
| http://purl.uniprot.org/uniprot/#_B4DM35-mappedCitation-21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21315262 |
| http://purl.uniprot.org/uniprot/#_B4DMA9-mappedCitation-21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21315262 |
| http://purl.uniprot.org/uniprot/#_A8K539-mappedCitation-21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21315262 |
| http://purl.uniprot.org/uniprot/#_B4DS63-mappedCitation-21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21315262 |
| http://purl.uniprot.org/uniprot/#_B4DSA9-mappedCitation-21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21315262 |
| http://purl.uniprot.org/uniprot/#_P01178-mappedCitation-21315262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21315262 |