| http://purl.uniprot.org/citations/21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21316588 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P₂] plays a fundamental role in clathrin-mediated endocytosis. However, precisely how PI(4,5)P₂ metabolism is spatially and temporally regulated during membrane internalization and the functional consequences of endocytosis-coupled PI(4,5)P₂ dephosphorylation remain to be explored. Using cell-free assays with liposomes of varying diameters, we show that the major synaptic phosphoinositide phosphatase, synaptojanin 1 (Synj1), acts with membrane curvature generators/sensors, such as the BAR protein endophilin, to preferentially remove PI(4,5)P₂ from curved membranes as opposed to relatively flat ones. Moreover, in vivo recruitment of Synj1's inositol 5-phosphatase domain to endophilin-induced membrane tubules results in fragmentation and condensation of these structures largely in a dynamin-dependent fashion. Our study raises the possibility that geometry-based mechanisms may contribute to spatially restricting PI(4,5)P₂ elimination during membrane internalization and suggests that the PI(4,5)P₂-to-PI4P conversion achieved by Synj1 at sites of high curvature may cooperate with dynamin to achieve membrane fission."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2010.12.008"xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/author | "Di Paolo G."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/author | "Roux A."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/author | "Chan R.B."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/author | "Chang-Ileto B."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/author | "Voronov S.V."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/author | "Frere S.G."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/pages | "206-218"xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/title | "Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission."xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/21316588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21316588 |
| http://purl.uniprot.org/citations/21316588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21316588 |
| http://purl.uniprot.org/uniprot/#_E9Q7S0-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_P63010-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_P63027-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_Q14247-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_Q15642-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_D3Z656-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_O15144-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_O15145-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |
| http://purl.uniprot.org/uniprot/#_P01130-mappedCitation-21316588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21316588 |