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http://purl.uniprot.org/citations/21317683http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21317683http://www.w3.org/2000/01/rdf-schema#comment"

Objective

An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.

Methods

We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.

Result

Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.

Conclusion

An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.org/dc/terms/identifier"doi:10.1097/ypg.0b013e3283437194"xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Hansen T."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Nothen M.M."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Rietschel M."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Andreassen O.A."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Djurovic S."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Borglum A.D."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Cichon S."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Mors O."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Del-Favero J."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Kallunki P."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Nyegaard M."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Pedersen J.T."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Martens G.J."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Adolfsson R."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Claes S."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Werge T."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Mortensen P.B."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Van Loo K.M."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Norrback K.F."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"De Hert M."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Sorensen K.M."xsd:string
http://purl.uniprot.org/citations/21317683http://purl.uniprot.org/core/author"Nordentoft M."xsd:string