| http://purl.uniprot.org/citations/21321306 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21321306 | http://www.w3.org/2000/01/rdf-schema#comment | "Renin synthesis and secretion by principal cells of the collecting duct are enhanced in angiotensin (Ang) II-dependent hypertension. The presence of renin/(pro)renin and its receptor, the (pro)renin receptor ([P]RR), in the collecting duct may provide a pathway for Ang I generation with further conversion to Ang II. To assess whether (P)RR activation occurs during Ang II-dependent hypertension, we examined renal (P)RR levels and soluble (P)RR excretion in the urine of chronic Ang II-infused rats (80 ng/min; for 2 weeks; n=10) and sham-operated rats (n=10). Systolic blood pressure and Ang II levels in the plasma and kidney were increased whereas plasma renin activity was suppressed in Ang II-infused rats. Renal (P)RR transcripts were upregulated in the cortex and medulla of Ang II-infused rats. (P)RR immunoreactivity in collecting duct cells and the protein levels of the full-length form (37-kDa band) were significantly decreased in the medulla of Ang II-infused rats. The soluble (P)RR (28-kDa band) was detected in the renal medulla and urine samples of Ang II-infused rats, which also showed increases in urinary renin content. To determine whether the soluble (P)RR could stimulate Ang I formation, urine samples were incubated with recombinant human (pro)renin. Urine samples of Ang II-infused rats exhibited increased Ang I formation compared with sham-operated rats. Thus, in chronic Ang II-infused rats, the catalytic activity of the augmented renin produced in the collecting duct may be enhanced by the intraluminal soluble (P)RR and cell-surface located (P)RR, thus contributing to enhanced intratubular Ang II formation."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.110.167957"xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/author | "Gonzalez A.A."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/author | "Lara L.S."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/author | "Prieto M.C."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/author | "Seth D.M."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/author | "Luffman C."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/pages | "859-864"xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/title | "Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats."xsd:string |
| http://purl.uniprot.org/citations/21321306 | http://purl.uniprot.org/core/volume | "57"xsd:string |
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