| http://purl.uniprot.org/citations/21324897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21324897 | http://www.w3.org/2000/01/rdf-schema#comment | "Our recent study showed that miR-2861 promotes osteoblast differentiation by targeting histone deacetylase 5, resulting in increased runt-related transcription factor 2 (Runx2) protein production. Here we identified another new microRNA (miRNA) (miR-3960) that played a regulatory role in osteoblast differentiation through a regulatory feedback loop with miR-2861. miR-3960 and miR-2861 were found clustered at the same loci. miR-3960 was transcribed during bone morphogenic protein 2 (BMP2)-induced osteogenesis of ST2 stromal cells. Overexpression of miR-3960 promoted BMP2-induced osteoblastogenesis. However, the inhibition of miR-3960 expression attenuated the osteoblastogenesis. Homeobox A2 (Hoxa2), a repressor of Runx2 expression, was confirmed to be a target of miR-3960. Electrophoretic mobility shift assay and chromatin immunoprecipitation experiments confirmed that Runx2 bound to the promoter of the miR-3960/miR-2861 cluster. Furthermore, overexpression of Runx2 induced miR-3960/miR-2861 transcription, and block of Runx2 expression attenuated BMP2-induced miR-3960/miR-2861 transcription. Here we report that miR-3960 and miR-2861, transcribed together from the same miRNA polycistron, both function in osteoblast differentiation through a novel Runx2/miR-3960/miR-2861 regulatory feedback loop. Our findings provide new insights into the roles of miRNAs in osteoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.176099"xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Hu R."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Xie H."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Guo L.J."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Xia Z.Y."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Wu X.P."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Luo X.H."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/author | "Zhou H.D."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/pages | "12328-12339"xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/title | "A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21324897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21324897 |
| http://purl.uniprot.org/citations/21324897 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21324897 |
| http://purl.uniprot.org/uniprot/P21274#attribution-CCBCE5F80F5723613698D9AA5656B6B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21324897 |
| http://purl.uniprot.org/uniprot/P31245#attribution-CCBCE5F80F5723613698D9AA5656B6B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21324897 |
| http://purl.uniprot.org/uniprot/P86546#attribution-CCBCE5F80F5723613698D9AA5656B6B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21324897 |
| http://purl.uniprot.org/uniprot/Q08775#attribution-CCBCE5F80F5723613698D9AA5656B6B3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21324897 |