| http://purl.uniprot.org/citations/21326863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21326863 | http://www.w3.org/2000/01/rdf-schema#comment | "LITAF is a small cellular protein with an unknown function. The C-terminus of LITAF contains a highly conserved domain termed the SIMPLE-like domain (SLD), while the N-terminus contains two PPXY motifs that mediate protein-protein interactions with WW-domain containing proteins. LITAF also harbors two endosome/lysosome targeting sequences at its C-terminus, but there has been conflicting reports regarding its intracellular localization. Here, we demonstrate that LITAF is localized to the late endosome/lysosomal compartment in a variety of cell lines. We also show that Itch, a WW-domain containing protein, and LITAF strongly interact and that this interaction depends on the two PPXY motifs in the N-terminus of LITAF. Interestingly, co-expression of LITAF with Itch induces major changes in Itch intracellular localization, bringing Itch from the trans-Golgi network to lysosomes. We show that this re-localization is dependent upon the interaction with the PPXY sequences of LITAF, since disruption of these binding motifs completely abrogates Itch re-localization."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0016873"xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/author | "Brunetti C.R."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/author | "Eaton H.E."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/author | "Metcalf J."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/author | "Angers A."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/author | "Desrochers G."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/author | "Drory S.B."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/pages | "e16873"xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/title | "SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments."xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21326863 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21326863 |
| http://purl.uniprot.org/citations/21326863 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21326863 |
| http://purl.uniprot.org/uniprot/#_B4DN85-mappedCitation-21326863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/#_Q59ER4-mappedCitation-21326863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/#_Q96J02-mappedCitation-21326863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/#_Q99732-mappedCitation-21326863 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/Q96J02 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/Q99732 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/B4DN85 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21326863 |
| http://purl.uniprot.org/uniprot/Q59ER4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21326863 |