| http://purl.uniprot.org/citations/21331046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21331046 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) function as initiators of inflammation through their ability to sense pathogen-associated molecular patterns and products of tissue damage. Transcriptional activation of many TLR-responsive genes requires an initial de-repression step in which nuclear receptor co-repressor (NCoR) complexes are actively removed from the promoters of target genes to relieve basal repression. Ligand-dependent SUMOylation of liver X receptors (LXRs) has been found to suppress TLR4-induced transcription potently by preventing the NCoR clearance step, but the underlying mechanisms remain enigmatic. Here we provide evidence that coronin 2A (CORO2A), a component of the NCoR complex of previously unknown function, mediates TLR-induced NCoR turnover by a mechanism involving interaction with oligomeric nuclear actin. SUMOylated LXRs block NCoR turnover by binding to a conserved SUMO2/SUMO3-interaction motif in CORO2A and preventing actin recruitment. Intriguingly, the LXR transrepression pathway can itself be inactivated by inflammatory signals that induce calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)-dependent phosphorylation of LXRs, leading to their deSUMOylation by the SUMO protease SENP3 and release from CORO2A. These findings uncover a CORO2A-actin-dependent mechanism for the de-repression of inflammatory response genes that can be differentially regulated by phosphorylation and by nuclear receptor signalling pathways that control immunity and homeostasis."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature09703"xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Czech M.P."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Goode B.L."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Rosenfeld M.G."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Aouadi M."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Saijo K."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Zhang D.X."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Gandhi M."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Ghisletti S."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/author | "Tesz G.J."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/pages | "414-418"xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/title | "Coronin 2A mediates actin-dependent de-repression of inflammatory response genes."xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://purl.uniprot.org/core/volume | "470"xsd:string |
| http://purl.uniprot.org/citations/21331046 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21331046 |
| http://purl.uniprot.org/citations/21331046 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21331046 |
| http://purl.uniprot.org/uniprot/#_B1AVH4-mappedCitation-21331046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21331046 |
| http://purl.uniprot.org/uniprot/#_B1AVH5-mappedCitation-21331046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21331046 |
| http://purl.uniprot.org/uniprot/#_Q3U8R5-mappedCitation-21331046 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21331046 |