| http://purl.uniprot.org/citations/21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21334226 | http://www.w3.org/2000/01/rdf-schema#comment | "Antiepileptic drugs-induced Stevens-Johnson syndrome (SJS) is a life-threatening severe cutaneous adverse reaction. Recent studies in Thailand and Taiwan showed a significant association between phenytoin (PHT)-induced SJS and human leucocyte antigen HLA-B*1502 allele. Although the US FDA had issued an alert to clinicians, insufficient information is available to recommend testing for HLA-B*1502 in Asian patients in line for PHT treatment. Therefore, extended studies are necessary to further evaluate the potential association between PHT-induced SJS and HLA-B*1502 allele in various populations. To date, no similar data exist in mainland China. Here, we describe two Chinese Han cases of PHT-induced SJS with negative HLA-B*1502 allele, in which HLA high-resolution genotyping showed two heterozygous HLA-B*4601/B*5102 and HLA-B*3701/B*4601 allele, respectively. Our findings provide evidence to support that other genetic markers or nongenetic factors could contribute to the susceptibility of PHT-induced SJS, except for HLA-B*1502 allele. Further studies are encouraged to investigate the genetic link with PHT-induced serious skin reactions in future."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.seizure.2011.01.005"xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/author | "Yan B."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/author | "Hu F.Y."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/author | "Wu X.T."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/author | "Stefan H."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/author | "An D.M."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/name | "Seizure"xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/pages | "431-432"xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/title | "Phenytoin-induced Stevens-Johnson syndrome with negative HLA-B*1502 allele in mainland China: two cases."xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/21334226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21334226 |
| http://purl.uniprot.org/citations/21334226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A068B116-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A068B2J5-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |
| http://purl.uniprot.org/uniprot/#_A0A068B2Z1-mappedCitation-21334226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21334226 |