| http://purl.uniprot.org/citations/21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21335604 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor protein BRCA1 is a constituent of several different protein complexes and is required for homology-directed repair (HDR) of DNA double strand breaks (DSBs). The most recently discovered BRCA1-RAP80 complex is recruited to ubiquitin structures on chromatin surrounding the break. Deficiency of any member of this complex confers hypersensitivity to DNA-damaging agents by undefined mechanisms. In striking contrast to other BRCA1-containing complexes that are known to promote HDR, we demonstrate that the BRCA1-RAP80 complex restricts end resection in S/G(2) phase of the cell cycle, thereby limiting HDR. RAP80 or BRCC36 deficiency resulted in elevated Mre11-CtIP-dependent 5' end resection with a concomitant increase in HDR mechanisms that rely on 3' single-stranded overhangs. We propose a model in which the BRCA1-RAP80 complex limits nuclease accessibility to DSBs, thus preventing excessive end resection and potentially deleterious homology-directed DSB repair mechanisms that can impair genome integrity."xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.213728"xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/author | "Greenberg R.A."xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/author | "Coleman K.A."xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/pages | "13669-13680"xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/title | "The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection."xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21335604 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21335604 |
| http://purl.uniprot.org/citations/21335604 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21335604 |
| http://purl.uniprot.org/uniprot/#_P49959-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_P38398-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_O60934-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q13315-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q96RL1-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q92878-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q92993-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q99708-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q99728-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/#_Q9NTC5-mappedCitation-21335604 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/Q96RL1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/P38398 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21335604 |
| http://purl.uniprot.org/uniprot/Q99728 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21335604 |