Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21337734http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21337734http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Pulmonary angiogenesis is a prerequisite for lung development. Angiopoietin-2 (Ang2) destabilizes endothelial cells through its endothelial receptor TIE-2, enabling vascular sprouting. Ang1 stabilizes new blood vessels. Soluble TIE-2 (sTIE-2) modulates these effects. We hypothesized that histological funisitis is associated with alterations of Ang2 in airways and of the systemic angiopoietin-TIE-2 homeostasis in very low birth weight (VLBW) infants, contributing to pulmonary morbidity and mortality.

Methods

We measured Ang2 in tracheobronchial aspirate fluid (TAF) of 42 VLBW <30 weeks of gestation from day 1 through 15 and Ang1, Ang2, and sTIE-2 in umbilical cord serum of 28 infants by enzyme-linked immunosorbent assay. Histological examination distinguished three groups: funisitis, chorioamnionitis, and controls.

Results

Funisitis was associated with lower Ang2 values in TAF but not with changes of Ang1, Ang2, and sTIE-2 in umbilical cord serum. Infants who developed bronchopulmonary dysplasia (BPD) or died had a persistently decreased ratio of previously measured Ang1 to Ang2 in TAF on days 1-5 and increased cord serum concentrations of sTIE-2. Moderate BPD/death was associated with an increase of Ang2 in TAF on day 10 and decreased Ang1/Ang2 ratio from day 3-15. Small for gestational age (SGA) infants had increased Ang2 in TAF on day 1-7 and a lower Ang1/Ang2 ratio on days 5-7.

Conclusions

The predominance of Ang2 in airway fluid of infants with BPD/death and SGA infants suggests a link between disrupted placental and fetal pulmonary angiogenesis. Histological funisitis with reduced Ang2 in TAF was of minor relevance for outcome in our cohort."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.org/dc/terms/identifier"doi:10.1002/ppul.21435"xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Thomas W."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Seidenspinner S."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Speer C.P."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Kramer B.W."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Kawczynska-Leda N."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Szymankiewicz M."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/author"Wirbelauer J."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/name"Pediatr Pulmonol"xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/pages"777-784"xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/title"Airway angiopoietin-2 in ventilated very preterm infants: association with prenatal factors and neonatal outcome."xsd:string
http://purl.uniprot.org/citations/21337734http://purl.uniprot.org/core/volume"46"xsd:string
http://purl.uniprot.org/citations/21337734http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21337734
http://purl.uniprot.org/citations/21337734http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21337734
http://purl.uniprot.org/uniprot/#_B2R6E3-mappedCitation-21337734http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/#_O15123-mappedCitation-21337734http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/#_Q9H4C0-mappedCitation-21337734http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/#_Q9H4C1-mappedCitation-21337734http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/#_Q9HBP3-mappedCitation-21337734http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/Q9HBP3http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/O15123http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21337734
http://purl.uniprot.org/uniprot/B2R6E3http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21337734
▶