| http://purl.uniprot.org/citations/21338947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21338947 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21338947 | http://www.w3.org/2000/01/rdf-schema#comment | "TRIpartite Motif (TRIM) family proteins are ring finger domain-containing, multi-domain proteins implicated in many biological processes. Members of the TRIM-9/C-I subfamily of TRIM proteins, including TRIM-9, MID1 and MID2, have neuronal functions and are associated with neurological diseases. To explore whether the functions of C-I TRIM proteins are conserved in invertebrates, we analyzed Caenorhabditis elegans and Drosophila trim-9 mutants. C. elegans trim-9 mutants exhibit defects in the ventral guidance of hermaphrodite specific neuron (HSN) and the touch neuron AVM. Further genetic analyses indicate that TRIM-9 participates in the UNC-6-UNC-40 attraction pathway. Asymmetric distribution of UNC-40 during HSN development is normal in trim-9 mutants. However, the asymmetric localization of MIG-10, a downstream effector of UNC-40, is abolished in trim-9 mutants. These results suggest that TRIM-9 functions upstream of MIG-10 in the UNC-40 pathway. Moreover, we showed that TRIM-9 exhibits E3 ubiquitin ligase activity in vitro and this activity is important for TRIM-9 function in vivo. Additionally, we found that Drosophila trim-9 is required for the midline attraction of a group of sensory neuron axons. Over-expression of the Netrin/UNC-6 receptor Frazzled suppresses the guidance defects in trim-9 mutants. Our study reveals an evolutionarily conserved function of TRIM-9 in the UNC-40/Frazzled-mediated UNC-6/Netrin attraction pathway."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jcg.2010.12.004"xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jcg.2010.12.004"xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Song S."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Tang S."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Tang S."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Xie Q."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Xie Q."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Bi J."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Bi J."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Ge Q."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/author | "Ge Q."xsd:string |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21338947 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |