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http://purl.uniprot.org/citations/21345006http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21345006http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

To explore the molecular mechanism of Vascular endothelial growth factor receptor-1 (VEGFR-1) in invasion and metastasis of hepatocellular carcinoma.

Methods

Reverse transcription polymerase chain reaction was performed to test expression of VEGFR-1 and its ligand VEGF-B19 in four hepatoma carcinoma cell. Fluorescent immunohistochemistry and western blotting were used to test the change of expression of E-cadherin or α-catenin.

Results

VEGF-B-treated cells exhibited a change in E-cadherin from an organized, membrane-bound structure to a disorganized state that was dispersed throughout the cytoplasm. The maximal changes in E-cadherin were observed 24 hr after treatment of cells with VEGF-B. α-catenin was observed to translocate to the nucleus from its usual membrane-bound location 24 hr after treatment with either VEGF-B. Expression of the epithelial adhesion molecules E-cadherin was observed to decrease 48 hours after VEGF-B treatment. The nuclear expression of α-catenin was observed to increase 24 hr after treatment with VEGF-B.

Conclusions

VEGFR-1 on tumor cells may contribute to the aggressive behavior of hepatocellular carcinoma cells by inducing epithelial to mesenchymal transition (EMT). Targeting VEGFR-1 and downstream mediators of EMT may provide the foundation for the development of novel therapeutic approaches for this morbid and lethal disease."xsd:string
http://purl.uniprot.org/citations/21345006http://purl.org/dc/terms/identifier"doi:10.3109/08941939.2010.542272"xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/author"Yao H."xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/author"Xiang Z."xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/author"Feng L.J."xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/author"Yi Z.Y."xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/name"J Invest Surg"xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/pages"67-76"xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/title"Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in hepatocellular carcinoma cells."xsd:string
http://purl.uniprot.org/citations/21345006http://purl.uniprot.org/core/volume"24"xsd:string
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