| http://purl.uniprot.org/citations/21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21346235 | http://www.w3.org/2000/01/rdf-schema#comment | "Newly discovered IL-9-producing helper T cells (Th9) reportedly exert both aggravating and suppressive roles on experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. However, it is still unclear whether Th9 is a distinct Th cell subset and how IL-9 functions in the CNS. In this study, we show that IL-9 is produced by naive CD4(+) T cells that were stimulated with anti-CD3 and anti-CD28 Abs under the conditions of Th2-, inducible regulatory T cell-, Th17-, and Th9-polarizing conditions and that IL-9 production is significantly suppressed in the absence of IL-4, suggesting that IL-4 is critical for the induction of IL-9 by each producing cell. The IL-9 receptor complex, IL-9R and IL-2Rγ, is constitutively expressed on astrocytes. IL-9 induces astrocytes to produce CCL-20 but not other chemokines, including CCL-2, CCL-3, and CXCL-2 by astrocytes. The conditioned medium of IL-9-stimulated astrocytes induces Th17 cell migration in vitro, which is cancelled by adding anti-CCL-20 neutralizing Abs. Treating with anti-IL-9 neutralizing Abs attenuates experimental autoimmune encephalomyelitis, decreases the number of infiltrating Th17 cells, and reduces CCL-20 expression in astrocytes. These results suggest that IL-9 is produced by several Th cell subsets in the presence of IL-4 and induces CCL-20 production by astrocytes to induce the migration of Th17 cells into the CNS."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1003307"xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Jin S."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Mizuno T."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Akahori T."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Kawanokuchi J."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Sonobe Y."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/author | "Suzumura A."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/pages | "4415-4421"xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/title | "IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes."xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21346235 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21346235 |
| http://purl.uniprot.org/citations/21346235 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21346235 |
| http://purl.uniprot.org/uniprot/#_Q62386-mappedCitation-21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21346235 |
| http://purl.uniprot.org/uniprot/#_F8WHA7-mappedCitation-21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21346235 |
| http://purl.uniprot.org/uniprot/#_G3UXB0-mappedCitation-21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21346235 |
| http://purl.uniprot.org/uniprot/#_Q642U4-mappedCitation-21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21346235 |
| http://purl.uniprot.org/uniprot/#_P07750-mappedCitation-21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21346235 |
| http://purl.uniprot.org/uniprot/#_Q91Y50-mappedCitation-21346235 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21346235 |