| http://purl.uniprot.org/citations/21350014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21350014 | http://www.w3.org/2000/01/rdf-schema#comment | "The temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels. We show that the miR302/367 cluster is a target of the transcription factor Gata6 in mouse lung endoderm and regulates multiple aspects of early lung endoderm progenitor development. miR302/367 is expressed at early stages of lung development, but its levels decline rapidly as development proceeds. Gain- and loss-of-function studies show that altering miR302/367 expression disrupts the balance of lung endoderm progenitor proliferation and differentiation, as well as apical-basal polarity. Increased miR302/367 expression results in the formation of an undifferentiated multi-layered lung endoderm, whereas loss of miR302/367 activity results in decreased proliferation and enhanced lung endoderm differentiation. miR302/367 coordinates the balance between proliferation and differentiation, in part, through direct regulation of Rbl2 and Cdkn1a, whereas apical-basal polarity is controlled by regulation of Tiam1 and Lis1. Thus, miR302/367 directs lung endoderm development by coordinating multiple aspects of progenitor cell behavior, including proliferation, differentiation and apical-basal polarity."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.061762"xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Hannenhalli S."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Lu M.M."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Morrisey E.E."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/author | "Hurd L."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/pages | "1235-1245"xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/title | "Regulation of lung endoderm progenitor cell behavior by miR302/367."xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/21350014 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21350014 |
| http://purl.uniprot.org/citations/21350014 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21350014 |
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