| http://purl.uniprot.org/citations/21354115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21354115 | http://www.w3.org/2000/01/rdf-schema#comment | "The recombination activating genes (RAGs) encode two enzymes that play key roles in the adaptive immune system. RAG1 and RAG2 mediate VDJ recombination, a process necessary for the maturation of B- and T-cells. Interestingly, RAG1 is also expressed in the brain, particularly in areas of high neural density such as the hippocampus, although its function is unknown. We tested evidence that RAG1 plays a role in brain function using a social recognition memory task, an assessment of the acquisition and retention of conspecific identity. In a first experiment, we found that RAG1-deficient mice show impaired social recognition memory compared to mice wildtype for the RAG1 allele. In a second experiment, by breeding to homogenize background genotype, we found that RAG1-deficient mice show impaired social recognition memory relative to heterozygous or RAG2-deficient littermates. Because RAG1 and RAG2 null mice are both immunodeficient, the results suggest that the memory impairment is not an indirect effect of immunological dysfunction. RAG1-deficient mice show normal habituation to non-socially derived odors and habituation to an open-field, indicating that the observed effect is not likely a result of a general deficit in habituation to novelty. These data trace the origin of the impairment in social recognition memory in RAG1-deficient mice to the RAG1 gene locus and implicate RAG1 in memory formation."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2011.02.054"xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/author | "Williams C.L."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/author | "Kelsoe G."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/author | "Meck W.H."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/author | "McGowan P.O."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/author | "Hope T.A."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/pages | "187-195"xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/title | "Impaired social recognition memory in recombination activating gene 1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://purl.uniprot.org/core/volume | "1383"xsd:string |
| http://purl.uniprot.org/citations/21354115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21354115 |
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