| http://purl.uniprot.org/citations/21356520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21356520 | http://www.w3.org/2000/01/rdf-schema#comment | "Impaired insulin secretion contributes to the pathogenesis of type 2 diabetes mellitus (T2DM). Treatment with the incretin hormone glucagon-like peptide-1 (GLP-1) potentiates insulin secretion and improves metabolic control in humans with T2DM. GLP-1 receptor-mediated signaling leading to insulin secretion occurs via cyclic AMP stimulated protein kinase A (PKA)-as well as guanine nucleotide exchange factor-mediated pathways. However, how these two pathways integrate and coordinate insulin secretion remains poorly understood. Here we show that these incretin-stimulated pathways converge at the level of snapin, and that PKA-dependent phosphorylation of snapin increases interaction among insulin secretory vesicle-associated proteins, thereby potentiating glucose-stimulated insulin secretion (GSIS). In diabetic islets with impaired GSIS, snapin phosphorylation is reduced, and expression of a snapin mutant, which mimics site-specific phosphorylation, restores GSIS. Thus, snapin is a critical node in GSIS regulation and provides a potential therapeutic target to improve β cell function in T2DM."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2011.02.002"xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Song W.J."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Stratakis C.A."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Mondal P."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Keil M."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Hussain M.A."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Kirschner L.S."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Ashraf U."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Azevedo M."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Seshadri M."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/author | "Mdluli T."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/pages | "308-319"xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/title | "Snapin mediates incretin action and augments glucose-dependent insulin secretion."xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/21356520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21356520 |
| http://purl.uniprot.org/citations/21356520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21356520 |
| http://purl.uniprot.org/uniprot/#_A2AI69-mappedCitation-21356520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21356520 |
| http://purl.uniprot.org/uniprot/#_F8S0Y0-mappedCitation-21356520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21356520 |
| http://purl.uniprot.org/uniprot/#_O95295-mappedCitation-21356520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21356520 |
| http://purl.uniprot.org/uniprot/#_Q3UY32-mappedCitation-21356520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21356520 |
| http://purl.uniprot.org/uniprot/#_Q3TYK4-mappedCitation-21356520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21356520 |