| http://purl.uniprot.org/citations/21357694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21357694 | http://www.w3.org/2000/01/rdf-schema#comment | "Using isogenic mouse embryonic fibroblasts and human cancer cell lines, we show that cells defective in base excision repair (BER) display a cisplatin-specific resistant phenotype. This was accompanied by enhanced repair of cisplatin interstrand cross-links (ICLs) and ICL-induced DNA double strand breaks, but not intrastrand adducts. Cisplatin induces abasic sites with a reduced accumulation in uracil DNA glycosylase (UNG) null cells. We show that cytosines that flank the cisplatin ICLs undergo preferential oxidative deamination in vitro, and AP endonuclease 1 (APE1) can cleave the resulting ICL DNA substrate following removal of the flanking uracil. We also show that DNA polymerase β has low fidelity at the cisplatin ICL site after APE1 incision. Down-regulating ERCC1-XPF in BER-deficient cells restored cisplatin sensitivity. Based on our results, we propose a novel model in which BER plays a positive role in maintaining cisplatin cytotoxicity by competing with the productive cisplatin ICL DNA repair pathways."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.225375"xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Brown A.R."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Sobol R.W."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Wang X.H."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Patrick S.M."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Banze L.A."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Dangeti V.S."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/author | "Kothandapani A."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/pages | "14564-14574"xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/title | "Novel role of base excision repair in mediating cisplatin cytotoxicity."xsd:string |
| http://purl.uniprot.org/citations/21357694 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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