| http://purl.uniprot.org/citations/21358630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21358630 | http://www.w3.org/2000/01/rdf-schema#comment | "Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore conceivable that chromatin-borne information participates in alternative splicing. Here we find that elevated levels of trimethylation of histone H3 on Lys9 (H3K9me3) are a characteristic of the alternative exons of several genes including CD44. On this gene the chromodomain protein HP1γ, frequently defined as a transcriptional repressor, facilitates inclusion of the alternative exons via a mechanism involving decreased RNA polymerase II elongation rate. In addition, accumulation of HP1γ on the variant region of the CD44 gene stabilizes association of the pre-mRNA with the chromatin. Altogether, our data provide evidence for localized histone modifications impacting alternative splicing. They further implicate HP1γ as a possible bridging molecule between the chromatin and the maturating mRNA, with a general impact on splicing decisions."xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1995"xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/author | "Batsche E."xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/author | "Muchardt C."xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/author | "Rachez C."xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/author | "Saint-Andre V."xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/pages | "337-344"xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/title | "Histone H3 lysine 9 trimethylation and HP1gamma favor inclusion of alternative exons."xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/21358630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21358630 |
| http://purl.uniprot.org/citations/21358630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21358630 |
| http://purl.uniprot.org/uniprot/#_B8ZZ43-mappedCitation-21358630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21358630 |
| http://purl.uniprot.org/uniprot/#_Q13185-mappedCitation-21358630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21358630 |
| http://purl.uniprot.org/uniprot/Q13185 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21358630 |
| http://purl.uniprot.org/uniprot/B8ZZ43 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21358630 |