| http://purl.uniprot.org/citations/21358643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21358643 | http://www.w3.org/2000/01/rdf-schema#comment | "We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein that, when mutated, causes amyotrophic lateral sclerosis. Massively parallel sequencing and splicing-sensitive junction arrays revealed that levels of 601 mRNAs were changed (including Fus (Tls), progranulin and other transcripts encoding neurodegenerative disease-associated proteins) and 965 altered splicing events were detected (including in sortilin, the receptor for progranulin) following depletion of TDP-43 from mouse adult brain with antisense oligonucleotides. RNAs whose levels were most depleted by reduction in TDP-43 were derived from genes with very long introns and that encode proteins involved in synaptic activity. Lastly, we found that TDP-43 autoregulates its synthesis, in part by directly binding and enhancing splicing of an intron in the 3' untranslated region of its own transcript, thereby triggering nonsense-mediated RNA degradation."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2779"xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Sun E."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Yeo G.W."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Moran J."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Bennett C.F."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Lagier-Tourenne C."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Shiue L."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Cleveland D.W."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Huelga S.C."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Mazur C."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Sedaghat Y."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Donohue J.P."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Polymenidou M."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Ling S.C."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Hutt K.R."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Liang T.Y."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Kordasiewicz H."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/author | "Wancewicz E."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/pages | "459-468"xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/title | "Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43."xsd:string |
| http://purl.uniprot.org/citations/21358643 | http://purl.uniprot.org/core/volume | "14"xsd:string |