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| http://purl.uniprot.org/citations/21361875 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic glucose metabolism is strongly influenced by oxidative stress and pro-inflammatory stimuli. PON2 (paraoxonase 2), an enzyme with undefined antioxidant properties, protects against atherosclerosis. PON2-deficient (PON2-def) mice have elevated hepatic oxidative stress coupled with an exacerbated inflammatory response from PON2-deficient macrophages. In the present paper, we demonstrate that PON2 deficiency is associated with inhibitory insulin-mediated phosphorylation of hepatic IRS-1 (insulin receptor substrate-1). Unexpectedly, we observed a marked improvement in the hepatic IRS-1 phosphorylation state in PON2-def/apoE (apolipoprotein E)(-/-) mice, relative to apoE(-/-) mice. Factors secreted from activated macrophage cultures derived from PON2-def and PON2-def/apoE(-/-) mice are sufficient to modulate insulin signalling in cultured hepatocytes in a manner similar to that observed in vivo. We show that the protective effect on insulin signalling in PON2-def/apoE(-/-) mice is directly associated with altered production of macrophage pro-inflammatory mediators, but not elevated intracellular oxidative stress levels. We further present evidence that modulation of the macrophage inflammatory response in PON2-def/apoE(-/-) mice is mediated by a shift in the balance of NO and ONOO(-) (peroxynitrite) formation. Our results demonstrate that PON2 plays an important role in hepatic insulin signalling and underscores the influence of macrophage-mediated inflammatory response on hepatic insulin sensitivity."xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20101891"xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/author | "Reddy S.T."xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/author | "Ng C.J."xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/author | "Bourquard N."xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/pages | "91-100"xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/title | "Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/21361875 | http://purl.uniprot.org/core/volume | "436"xsd:string |
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