| http://purl.uniprot.org/citations/21368224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21368224 | http://www.w3.org/2000/01/rdf-schema#comment | "The common lymphatic endothelial and vascular endothelial receptor (CLEVER-1; also known as FEEL-1 and stabilin-1) is a recycling and intracellular trafficking receptor with multifunctional properties. In this study, we demonstrate increased endothelial expression of CLEVER-1/stabilin-1 at sites of leukocyte recruitment to the inflamed human liver including sinusoids, septal vessels, and lymphoid follicles in inflammatory liver disease and tumor-associated vessels in hepatocellular carcinoma. We used primary cultures of human hepatic sinusoidal endothelial cells (HSEC) to demonstrate that CLEVER-1/stabilin-1 expression is enhanced by hepatocyte growth factor but not by classical proinflammatory cytokines. We then showed that CLEVER-1/stabilin-1 supports T cell transendothelial migration across HSEC under conditions of flow with strong preferential activity for CD4 FoxP3(+) regulatory T cells (Tregs). CLEVER-1/stabilin-1 inhibition reduced Treg transendothelial migration by 40% and when combined with blockade of ICAM-1 and vascular adhesion protein-1 (VAP-1) reduced it by >80%. Confocal microscopy demonstrated that 60% of transmigrating Tregs underwent transcellular migration through HSEC via ICAM-1- and VAP-1-rich transcellular pores in close association with CLEVER-1/stabilin-1. Thus, CLEVER-1/stabilin-1 and VAP-1 may provide an organ-specific signal for Treg recruitment to the inflamed liver and to hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002961"xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Shetty S."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Jalkanen S."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Salmi M."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Adams D.H."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Lalor P.F."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Stamataki Z."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Westerlund N."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Hubscher S.G."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Weston C.J."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Oo Y.H."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/author | "Youster J."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/pages | "4147-4155"xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/title | "Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium."xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21368224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21368224 |
| http://purl.uniprot.org/citations/21368224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21368224 |
| http://purl.uniprot.org/uniprot/#_Q0PNF2-mappedCitation-21368224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21368224 |
| http://purl.uniprot.org/uniprot/#_B3KSK0-mappedCitation-21368224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21368224 |
| http://purl.uniprot.org/uniprot/#_Q9NY15-mappedCitation-21368224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21368224 |
| http://purl.uniprot.org/uniprot/Q9NY15 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21368224 |