| http://purl.uniprot.org/citations/21376232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21376232 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21376232 | http://www.w3.org/2000/01/rdf-schema#comment | "A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain. PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter. Conditional knockout of parkin in adult animals leads to progressive loss of dopamine (DA) neurons in a PARIS-dependent manner. Moreover, overexpression of PARIS leads to the selective loss of DA neurons in the substantia nigra, and this is reversed by either parkin or PGC-1α coexpression. The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.02.010"xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.02.010"xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Lee Y."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Shin J.H."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Shin J.H."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Dawson T.M."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Dawson V.L."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Ko H.S."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Ko H.S."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Lee Y.I."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Lee Y.I."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Pletinkova O."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Pletinkova O."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Troconso J.C."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/author | "Troconso J.C."xsd:string |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21376232 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |