| http://purl.uniprot.org/citations/21378193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21378193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21378193 | http://www.w3.org/2000/01/rdf-schema#comment | "The Spx protein of Bacillus subtilis is a global regulator of the oxidative stress response. Spx concentration is controlled at the level of proteolysis by the ATP-dependent protease ClpXP and a substrate-binding protein, YjbH, which interacts with Spx. A yeast two-hybrid screen was carried out using yjbH as bait to uncover additional substrates or regulators of YjbH activity. Of the several genes identified in the screen, one encoded a small protein, YirB (YuzO), which elevated Spx concentration and activity in vivo when overproduced from an isopropyl-β-D-thiogalactopyranoside (IPTG)-inducible yirB construct. Pulldown experiments using extracts of B. subtilis cells producing a His-tagged YirB showed that native YjbH interacts with YirB in B. subtilis. Pulldown experiments using affinity-tagged Spx showed that YirB inhibited YjbH interaction with Spx. In vitro, YjbH-mediated proteolysis of Spx by ClpXP was inhibited by YirB. The activity of YirB is similar to that of the antiadaptor proteins that were previously shown to reduce proteolysis of a specific ClpXP substrate by interacting with a substrate-binding protein."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.01350-10"xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.01350-10"xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Zuber P."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Zuber P."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Garg S.K."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Garg S.K."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Chan C.M."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Chan C.M."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Kommineni S."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/author | "Kommineni S."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/name | "J. Bacteriol."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/pages | "2133-2140"xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/pages | "2133-2140"xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/title | "YjbH-enhanced proteolysis of Spx by ClpXP in Bacillus subtilis is inhibited by the small protein YirB (YuzO)."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/title | "YjbH-enhanced proteolysis of Spx by ClpXP in Bacillus subtilis is inhibited by the small protein YirB (YuzO)."xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/21378193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21378193 |
| http://purl.uniprot.org/citations/21378193 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21378193 |