| http://purl.uniprot.org/citations/21378755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21378755 | http://www.w3.org/2000/01/rdf-schema#comment | "The structural basis of the tRNA selection process is investigated by cryo-electron microscopy of ribosomes programmed with UGA codons and incubated with ternary complex (TC) containing the near-cognate Trp-tRNA(Trp) in the presence of kirromycin. Going through more than 350 000 images and employing image classification procedures, we find ∼8% in which the TC is bound to the ribosome. The reconstructed 3D map provides a means to characterize the arrangement of the near-cognate aa-tRNA with respect to elongation factor Tu (EF-Tu) and the ribosome, as well as the domain movements of the ribosome. One of the interesting findings is that near-cognate tRNA's acceptor stem region is flexible and CCA end becomes disordered. The data bring direct structural insights into the induced-fit mechanism of decoding by the ribosome, as the analysis of the interactions between small and large ribosomal subunit, aa-tRNA and EF-Tu and comparison with the cognate case (UGG codon) offers clues on how the conformational signals conveyed to the GTPase differ in the two cases."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.58"xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Frank J."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Lei J."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Schreiner E."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Schulten K."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Trabuco L.G."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Agirrezabala X."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Green R."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/author | "Ortiz-Meoz R.F."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/pages | "1497-1507"xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/title | "Structural insights into cognate versus near-cognate discrimination during decoding."xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21378755 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21378755 |
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