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| http://purl.uniprot.org/citations/21378974 | http://www.w3.org/2000/01/rdf-schema#comment | "The absence of the chloride channel CLC-3 in Clcn3(-/-) mice results in hippocampal degeneration with a distinct temporal-spatial sequence that resembles neuronal loss in temporal lobe epilepsy. We examined how the loss of CLC-3 might affect GABAergic synaptic transmission in the hippocampus. An electrophysiological study of synaptic function in hippocampal slices taken from Clcn3(-/-) mice before the onset of neurodegeneration revealed a substantial decrease in the amplitude and frequency of miniature inhibitory postsynaptic currents compared with those in wild-type slices. We found that CLC-3 colocalized with the vesicular GABA transporter VGAT in the CA1 region of the hippocampus. Acidification of inhibitory synaptic vesicles induced by Cl(-) showed a marked dependence on CLC-3 expression. The decrease in inhibitory transmission in Clcn3(-/-) mice suggests that the neurotransmitter loading of synaptic vesicles was reduced, which we attribute to defective vesicular acidification. Our observations extend the role of Cl(-) in inhibitory transmission from that of a postsynaptic permeant species to a presynaptic regulatory element."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2775"xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/author | "Le B."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/author | "Nelson D.J."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/author | "Gomez E.A."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/author | "Deriy L.V."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/author | "Shevchenko P.D."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/author | "Riazanski V."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/pages | "487-494"xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/title | "Presynaptic CLC-3 determines quantal size of inhibitory transmission in the hippocampus."xsd:string |
| http://purl.uniprot.org/citations/21378974 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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