| http://purl.uniprot.org/citations/21380526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21380526 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21380526 | http://www.w3.org/2000/01/rdf-schema#comment | "To optimize Chinese hamster ovary (CHO) cell culture to recombinant protein therapeutic production, we stably overexpressed survivin and cyclin D1 in three CHO DG44-derived cell lines. The modifications conferred increases of 56-94% in S-phase fractions and decreases of 33-43% in early-stage apoptosis fractions. Clone 6.3, which expressed the highest levels of survivin and cyclin D1, reached significantly greater cell densities in suspension (2.7 × 10(6) cells/ml) following serum deprivation. Nude mice inoculated with the modified cells showed no tumorigenesis suggesting that the CHO DG44-derived cell lines are viable candidates for biopharmaceutical production."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10529-011-0577-9"xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10529-011-0577-9"xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Hou L."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Hou L."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Fu L."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Fu L."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Yu Y."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Zhao X."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Yi S."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Yi S."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Yu T."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/author | "Yu T."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/name | "Biotechnol. Lett."xsd:string |
| http://purl.uniprot.org/citations/21380526 | http://purl.uniprot.org/core/name | "Biotechnol Lett"xsd:string |