| http://purl.uniprot.org/citations/21383019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21383019 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic inflammation is an important component that contributes to many age-related neurodegenerative diseases, including macular degeneration. Here, we report a role for toll-like receptor 3 (TLR3) in cone-rod dystrophy (CORD) of mice lacking ATP-binding cassette transporter 4 (ABCA4) and retinol dehydrogenase 8 (RDH8), proteins critical for all-trans-retinal clearance in the retina. Increased expression of toll-like receptor-signaling elements and inflammatory changes were observed in Rdh8(-/-)Abca4(-/-) eyes by RNA expression analysis. Unlike 3-month-old Rdh8(-/-)Abca4(-/-) mice that developed CORD, 6-month-old Tlr3(-/-)Rdh8(-/-)Abca4(-/-) mice did not evidence an abnormal retinal phenotype. Light-induced retinal degeneration in Tlr3(-/-)Rdh8(-/-)Abca4(-/-) mice was milder than that in Rdh8(-/-)Abca4(-/-) mice, and a 2-fold increased TLR3 expression was detected in light-illuminated retinas of Rdh8(-/-)Abca4(-/-) mice compared with nonilluminated retinas. Poly(I-C), a TLR3 ligand, caused caspase-8-independent cellular apoptosis. Whereas poly(I-C) induced retinal cell death in Rdh8(-/-)Abca4(-/-) and WT mice both in vivo and ex vivo, this was not seen in mice lacking Tlr3. Far fewer invasive macrophage/microglial cells in the subretinal space and weaker activation of Muller glial cells were exhibited by Tlr3(-/-)Rdh8(-/-) Abca4(-/-) mice compared with Rdh8(-/-)Abca4(-/-) mice at 3 and 6 months of age, indicating that loss of TLR3 inhibits local inflammation in the retina. Both poly(I-C) and endogenous products emanating from dying/dead retinal cells induced NF-κB and IRF3 activation. These findings demonstrate that endogenous products from degenerating retina stimulate TLR3 that causes cellular apoptosis and retinal inflammation and that loss of TLR3 protects mice from CORD."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.228551"xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Maeda A."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Okano K."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Maeda T."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Roy S."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Kohno H."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Palczewski K."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Pearlman E."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/author | "Shiose S."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/pages | "15543-15555"xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/title | "Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice."xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21383019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21383019 |
| http://purl.uniprot.org/citations/21383019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21383019 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG8-mappedCitation-21383019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21383019 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA2-mappedCitation-21383019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21383019 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VI41-mappedCitation-21383019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21383019 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS40-mappedCitation-21383019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21383019 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GSY9-mappedCitation-21383019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21383019 |