Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21384500http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21384500http://www.w3.org/2000/01/rdf-schema#comment"

Background

Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expression of GLP-1. We investigated the effect of the allelic variants rs1225537 and rs7903146 in TCF7L2 on the age at onset of type 2 diabetes, the plasma concentrations of proinsulin and GLP-1, and the ratio of proinsulin to insulin in a German cohort.

Methods

We studied 3185 participants of the LUdwigshafen RIsk and Cardiovascular health (LURIC) study. Among these, 1021 subjects had type 2 diabetes. Data on age at onset of diabetes were available in 925 subjects. OGTTs were performed in a subgroup not previously known to have diabetes.

Results

Carriers of the risk alleles in rs1225537 and rs7901346 had increased risk of type 2 diabetes and elevated HbA(1c) (all p < 0.001). The risk alleles were also associated with early onset of type 2 diabetes, decreased insulin secretion and markedly increased proinsulin and proinsulin to insulin ratio (all p < 0.03). GLP-1 was not significantly related to the TCF7L2 genotype.

Conclusions

Our data demonstrate that TCF7L2 variants are associated with an early age of onset of type 2 diabetes in Caucasians and affects the conversion of proinsulin to insulin. However, TCF7L2 is not consistently associated with fasting GLP-1."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.org/dc/terms/identifier"doi:10.1002/dmrr.1194"xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Hoffmann M.M."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Marz W."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Renner W."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Boehm B.O."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Bertram J."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Winkelmann B.R."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Grammer T.B."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Silbernagel G."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Kleber M.E."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/author"Hugl S.R."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/name"Diabetes Metab Res Rev"xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/pages"499-505"xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/title"Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1."xsd:string
http://purl.uniprot.org/citations/21384500http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/21384500http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21384500
http://purl.uniprot.org/citations/21384500http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21384500
http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-21384500http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21384500
http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-21384500http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21384500
http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-21384500http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21384500
http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-21384500http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21384500
http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-21384500http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21384500
▶