| http://purl.uniprot.org/citations/21385766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21385766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21385766 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Slit family of secreted ligands interact with Roundabout (Robo) receptors to provide guidance cues for many cell types. For example, Slit/Robo signaling elicits repulsion of axons during neural development, whereas in endothelial cells this pathway inhibits or promotes angiogenesis depending on the cellular context. Here, we show that miR-218 is intronically encoded in slit2 and slit3 and that it suppresses Robo1 and Robo2 expression. Our data indicate that miR-218 and multiple Slit/Robo signaling components are required for heart tube formation in zebrafish and that this network modulates the previously unappreciated function of Vegf signaling in this process. These findings suggest a new paradigm for microRNA-based control of ligand-receptor interactions and provide evidence for a novel signaling pathway regulating vertebrate heart tube assembly."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.060046"xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Xiao T."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Xiao T."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Srivastava D."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Srivastava D."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Stainier D.Y."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Stainier D.Y."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Woo S."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Woo S."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Fish J.E."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Fish J.E."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Bruneau B.G."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Bruneau B.G."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Wythe J.D."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/author | "Wythe J.D."xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/pages | "1409-1419"xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/pages | "1409-1419"xsd:string |
| http://purl.uniprot.org/citations/21385766 | http://purl.uniprot.org/core/title | "A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish."xsd:string |