| http://purl.uniprot.org/citations/21385853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21385853 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8(+) T cells in the liver, the major first site of AML metastases. PD-1 and Tim-3 coexpression increased during AML progression. PD-1(+)Tim-3(+) CD8(+) T cells were deficient in their ability to produce IFN-γ, TNF-α, and IL-2 in response to PD-1 ligand (PDL1) and Tim-3 ligand (galectin-9) expressing AML cells. PD-1 knockout (KO), which were partially resistant to AML challenge, up-regulated Tim-3 during AML progression and such Tim-3(+)PD-1-KO CD8(+) T cells had reduced cytokine production. Galectin-9 KO mice were more resistant to AML, which was associated with reduced T-regulatory cell accumulation and a modest induction of PD-1 and Tim-3 expression on CD8(+) T cells. Whereas blocking the PD-1/PDL1 or Tim-3/galectin-9 pathway alone was insufficient to rescue mice from AML lethality, an additive effect was seen in reducing-albeit not eliminating-both tumor burden and lethality when both pathways were blocked. Therefore, combined PD-1/PDL1 and Tim-3/galectin-9 blockade may be beneficial in preventing CD8(+) T-cell exhaustion in patients with hematologic malignancies such as advanced AML."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-10-310425"xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Anderson A.C."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Murphy W.J."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Weigel B.J."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Hirashima M."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Kuchroo V.K."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Munn D.H."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Veenstra R.G."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/author | "Munger M.E."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/pages | "4501-4510"xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/title | "Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia."xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21385853 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21385853 |
| http://purl.uniprot.org/citations/21385853 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21385853 |
| http://purl.uniprot.org/uniprot/#_B1AQR8-mappedCitation-21385853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21385853 |
| http://purl.uniprot.org/uniprot/#_D3Z3I4-mappedCitation-21385853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21385853 |
| http://purl.uniprot.org/uniprot/#_G3X9T7-mappedCitation-21385853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21385853 |
| http://purl.uniprot.org/uniprot/#_Q02242-mappedCitation-21385853 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21385853 |