| http://purl.uniprot.org/citations/21396779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21396779 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether δ-subunit-containing GABA(A)Rs (δGABA(A)Rs) in neurons of the spinal cord dorsal horn generate a tonic inhibitory conductance in vitro and whether δGABA(A)R activity regulates acute nociception. Whole-cell recordings revealed that δGABA(A)Rs generate a tonic inhibitory conductance in cultured spinal neurons and lamina II neurons in spinal cord slices. Increasing δGABA(A)R function by applying the δGABA(A)R-preferring agonist 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol (THIP) increased the tonic current and inhibited neuronal excitability in spinal neurons from wild-type (WT) but not δ subunit null-mutant (Gabrd(-/-)) mice. In behavioral studies, baseline δGABA(A)R activity did not regulate acute nociception; however, THIP administered intraperitoneally or intrathecally attenuated acute nociception in WT but not Gabrd(-/-) mice. In the formalin nociception assay, the phase 1 response was similar for WT and Gabrd(-/-) mice. In contrast, the phase 2 response, which models central sensitization, was greater in Gabrd(-/-) mice than WT. THIP administered intraperitoneally or intrathecally inhibited phase 1 responses of WT but not Gabrd(-/-) mice and had no effect on phase 2 responses of WT mice. Surprisingly, THIP reduced the enhanced phase 2 response in Gabrd(-/-) mice. Together, these results suggest that δGABA(A)Rs in spinal neurons play a major physiological and pharmacological role in the regulation of acute nociception and central sensitization. Spinal δ-subunit-containing GABA(A) receptors were identified with electrophysiological methods and behavioral models as novel targets for the treatment of acute pain."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.pain.2011.02.011"xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/author | "De Koninck Y."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/author | "Orser B.A."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/author | "Bonin R.P."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/author | "Eng D.G."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/author | "Labrakakis C."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/author | "Whissell P.D."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/name | "Pain"xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/pages | "1317-1326"xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/title | "Pharmacological enhancement of delta-subunit-containing GABA(A) receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice."xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/21396779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21396779 |
| http://purl.uniprot.org/citations/21396779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21396779 |
| http://purl.uniprot.org/uniprot/#_Q14AH9-mappedCitation-21396779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21396779 |
| http://purl.uniprot.org/uniprot/#_P22933-mappedCitation-21396779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21396779 |
| http://purl.uniprot.org/uniprot/#_Q8VBV6-mappedCitation-21396779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21396779 |
| http://purl.uniprot.org/uniprot/Q8VBV6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21396779 |
| http://purl.uniprot.org/uniprot/P22933 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21396779 |
| http://purl.uniprot.org/uniprot/Q14AH9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21396779 |