| http://purl.uniprot.org/citations/21397192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21397192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21397192 | http://www.w3.org/2000/01/rdf-schema#comment | "IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins. It has been implicated in transcriptional regulation by modulating protein-protein interactions with p53 tumor suppressor protein and other transcription factors. However, the mechanisms of interaction remain unknown. Here, we report the crystal structures of both HIN-A and HIN-B domains of IFI16 determined at 2.0 and 2.35 Å resolution, respectively. Each HIN domain comprises a pair of tightly packed OB-fold subdomains that appear to act as a single unit. We show that both HIN domains of IFI16 are capable of enhancing p53-DNA complex formation and transcriptional activation via distinctive means. HIN-A domain binds to the basic C terminus of p53, whereas the HIN-B domain binds to the core DNA-binding region of p53. Both interactions are compatible with the DNA-bound state of p53 and together contribute to the effect of full-length IFI16 on p53-DNA complex formation and transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2010.12.015"xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2010.12.015"xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Arrowsmith C.H."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Arrowsmith C.H."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Duan S."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Duan S."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Wang Y.X."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Wang Y.X."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Tempel W."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Tempel W."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Ravichandran M."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Ravichandran M."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Chirgadze N.Y."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Chirgadze N.Y."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Xiao T."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Xiao T."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Liao J.C."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Liao J.C."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Zuo X."xsd:string |
| http://purl.uniprot.org/citations/21397192 | http://purl.uniprot.org/core/author | "Zuo X."xsd:string |