| http://purl.uniprot.org/citations/21399661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21399661 | http://www.w3.org/2000/01/rdf-schema#comment | "Lung cancer is the most common cause of cancer-related mortality worldwide. Here, we report elevated expression of tribbles homolog 2 (TRIB2) in primary human lung tumors and in non-small cell lung cancer cells that express low levels of differentiation-inducing transcription factor CCAAT/enhancer-binding protein alpha (C/EBPα). In approximately 10-20% of cases, elevated TRIB2 expression resulted from gene amplification. TRIB2 knockdown was found to inhibit cell proliferation and in vivo tumor growth. In addition, TRIB2 knockdown led to morphological changes similar to C/EBPα overexpression and correlated with increased expression and activity of C/EBPα. TRIB2-mediated regulation of C/EBPα was found to occur through the association of TRIB2 with the E3 ligase TRIM21. Together, these data identify TRIB2 as a potential driver of lung tumorigenesis through a mechanism that involves downregulation of C/EBPα."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2011.57"xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Agarwalla S."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Walker J.R."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Peters E.C."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Stevens T.A."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Ha S."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Reddy V.A."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Grandinetti K.B."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/author | "Salamone R.J."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/pages | "3328-3335"xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/title | "Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPalpha."xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21399661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21399661 |
| http://purl.uniprot.org/citations/21399661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21399661 |
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| http://purl.uniprot.org/uniprot/Q6P3S4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21399661 |