| http://purl.uniprot.org/citations/21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21400499 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-22 is a Th17 cytokine that plays a key role in immune responses against extracellular bacteria. In mucosal lymphoid tissues, IL-22 production is mainly due to an IL-23-responsive NK-like cell subset that shares some markers with lymphoid tissue inducer (LTi) cells. Here, we identified a new spleen cell population responsible for IL-22 production upon either in vitro stimulation by anti-CD3 antibodies or in vivo stimulation by lipopolysaccharide (LPS) via IL-2- and an IL-23-dependent mechanisms, respectively. These cells represent 1% of spleen cells from recombination activating gene (Rag2)-deficient mice, and correspond to a discrete innate lymphoid cell population expressing CD25, CCR6 and IL-7R. This population comprises 60-70% CD4(+) cells, which produce IL-22, and are still present in common γ chain-deficient mice; the CD4(-) subset coexpresses IL-22 and IL-17, and is common γ chain-dependent. The importance of IL-22 production for the LPS-triggered response is highlighted by the fact that IL-22-deficient mice are more resistant to LPS-induced mortality."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201040878"xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Di Santo J.P."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Renauld J.C."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Dumoutier L."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Eberl G."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Orabona C."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Sirard J.C."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "de Heusch M."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/author | "Satoh-Takayama N."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/pages | "1075-1085"xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/title | "IL-22 is produced by gammaC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality."xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/21400499 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21400499 |
| http://purl.uniprot.org/citations/21400499 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21400499 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV04-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |
| http://purl.uniprot.org/uniprot/#_A0A338P732-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |
| http://purl.uniprot.org/uniprot/#_F8WJ69-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |
| http://purl.uniprot.org/uniprot/#_A2AVE0-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |
| http://purl.uniprot.org/uniprot/#_B7ZD65-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |
| http://purl.uniprot.org/uniprot/#_P01590-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |
| http://purl.uniprot.org/uniprot/#_Q3THW2-mappedCitation-21400499 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21400499 |