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http://purl.uniprot.org/citations/21401930http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21401930http://www.w3.org/2000/01/rdf-schema#comment"

Background

Mitogen-activated protein kinase (MAPK) cascades (p38, JNK, ERK pathways) are involved in cell fate acquisition during development. These kinase modules are associated with scaffold proteins that control their activity. In Drosophila, dMP1, that encodes an ERK scaffold protein, regulates ERK signaling during wing development and contributes to intervein and vein cell differentiation. Functional relationships during wing development between a chromatin regulator, the Enhancer of Trithorax and Polycomb Corto, ERK and its scaffold protein dMP1, are examined here.

Results

Genetic interactions show that corto and dMP1 act together to antagonize rolled (which encodes ERK) in the future intervein cells, thus promoting intervein fate. Although Corto, ERK and dMP1 are present in both cytoplasmic and nucleus compartments, they interact exclusively in nucleus extracts. Furthermore, Corto, ERK and dMP1 co-localize on several sites on polytene chromosomes, suggesting that they regulate gene expression directly on chromatin. Finally, Corto is phosphorylated. Interestingly, its phosphorylation pattern differs between cytoplasm and nucleus and changes upon ERK activation.

Conclusions

Our data therefore suggest that the Enhancer of Trithorax and Polycomb Corto could participate in regulating vein and intervein genes during wing tissue development in response to ERK signaling."xsd:string
http://purl.uniprot.org/citations/21401930http://purl.org/dc/terms/identifier"doi:10.1186/1471-213x-11-17"xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/author"Peronnet F."xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/author"Mouchel-Vielh E."xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/author"Decoville M."xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/author"Rougeot J."xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/name"BMC Dev Biol"xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/pages"17"xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/title"The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development."xsd:string
http://purl.uniprot.org/citations/21401930http://purl.uniprot.org/core/volume"11"xsd:string
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