| http://purl.uniprot.org/citations/21402741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21402741 | http://www.w3.org/2000/01/rdf-schema#comment | "Memory T helper cells (Th cells) play an important role in host defense against pathogens but also contribute to the pathogenesis of inflammatory disorders. We found that a soluble decoy lymphotoxin β receptor (LT-βR)-Fc, which can block tumor necrosis factor (TNF)-related ligands LIGHT (TNFSF14) and LT-αβ binding to the herpesvirus entry mediator (HVEM) and the LT-βR, inhibited the accumulation of memory Th2 cells after antigen encounter and correspondingly reduced inflammatory responses in vivo. Showing that this was a function of the receptor for LIGHT, antigen-specific memory CD4 T cells deficient in HVEM were also unable to persist, despite having a normal immediate response to recall antigen. HVEM(-/-) memory Th2 cells displayed reduced activity of PKB (protein kinase B; Akt), and constitutively active Akt rescued their survival and restored strong inflammation after antigen rechallenge. This was not restricted to Th2 memory cells as HVEM-deficient Th1 memory cells were also impaired in surviving after encounter with recall antigen. Furthermore, the absence of LIGHT on T cells recapitulated the defect seen with the absence of HVEM, suggesting that activated T cells communicate through LIGHT-HVEM interactions. Collectively, our results demonstrate a critical role of HVEM signals in the persistence of large pools of memory CD4 T cells."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20101562"xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "So T."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Norris P.S."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Pfeffer K."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Croft M."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Scheu S."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Mehta A.K."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Ware C."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Soroosh P."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Doherty T.A."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/author | "Khorram N."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/pages | "797-809"xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/title | "Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations."xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://purl.uniprot.org/core/volume | "208"xsd:string |
| http://purl.uniprot.org/citations/21402741 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21402741 |
| http://purl.uniprot.org/citations/21402741 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21402741 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA8-mappedCitation-21402741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21402741 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P889-mappedCitation-21402741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21402741 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P6M8-mappedCitation-21402741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21402741 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7D5-mappedCitation-21402741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21402741 |
| http://purl.uniprot.org/uniprot/#_B2RRV3-mappedCitation-21402741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21402741 |