| http://purl.uniprot.org/citations/21402891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21402891 | http://www.w3.org/2000/01/rdf-schema#comment | "The FcγRs found on macrophages (Ms) and dendritic cells (DCs) efficiently facilitate the presentation or cross-presentation of immune-complexed Ags to T cells. We found that the MHC class I-related neonatal FcR for IgG (FcRn) in both Ms and DCs failed to have a strong effect on the cross-presentation of immune complex (IC) OVA Ag to CD8(+) T cells. Interestingly, endosomal FcRn enhanced the presentation of the monomeric OVA-IC to CD4(+) T cells robustly, whereas FcRn in phagosomes exerted distinctive effects on Ag presentation between Ms and DCs. The presentation of phagocytosed OVA-ICs to CD4(+) T cells was considerably enhanced on wild-type versus FcRn-deficient Ms, but was not affected in FcRn-deficient DCs. This functional discrepancy was associated with the dependence of IgG-FcRn binding in an acidic pH. Following phagocytosis, the phagosomal pH dropped rapidly to <6.5 in Ms but remained in the neutral range in DCs. This disparity in pH determined the rate of degradation of phagocytosed ICs. Thus, our findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1003584"xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Zeng R."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Mosser D.M."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Roopenian D.C."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Gao L.Y."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/author | "Palaniyandi S."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/pages | "4674-4686"xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/title | "The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21402891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21402891 |
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| http://purl.uniprot.org/uniprot/#_Q61559-mappedCitation-21402891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21402891 |
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