| http://purl.uniprot.org/citations/21403679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21403679 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroblastoma (NB)-associated endothelial microvessels (EMs) may be lined by tumor-derived endothelial cells (TECs), that are genetically unstable and chemoresistant. Here we have addressed the identification of TEC progenitors in NB by focusing on Octamer-binding transcription factor 4 (Oct-4) as a putative marker. Oct-4(+) cells were detected in primary NB samples (n = 23), metastatic bone marrow aspirates (n = 10), NB cell lines (n = 4), and orthotopic tumors (n = 10) formed by the HTLA-230 NB cell line in immunodeficient mice. Most Oct-4(+) cells showed a perivascular distribution, with 5% of them homing in perinecrotic areas. All Oct-4(+) cells were tumor-derived since they shared amplification of MYCN oncogene with malignant cells. Perivascular Oct-4(+) cells expressed stem cell-related, neural progenitor-related and NB-related markers, including surface Tenascin C (TNC), that was absent from perinecrotic Oct-4(+) cells and bulk tumor cells. TNC(+) but not TNC(-) HTLA-230 cells differentiated in vitro into endothelial-like cells expressing vascular-endothelial-cadherin, prostate-specific membrane antigen and CD31 upon culture in medium containing vascular endothelial growth factor (VEGF). TNC(+) but not TNC(-) HTLA-230 cells formed neurospheres when cultured in serum-free medium. Both cell fractions were tumorigenic, but only tumors formed by TNC(+) cells contained EMs lined by TECs. In conclusion, we have identified in NB tumors two putative niches containing Oct-4(+) tumor cells. Oct-4(+)/TNC(+) perivascular NB cells displayed a high degree of plasticity and served as progenitors of TECs. Therapeutic targeting of Oct4(+)/TNC(+) progenitors may counteract the contribution of NB-derived ECs to tumor relapse and chemoresistance."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2011.38"xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Malavasi F."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Mosconi M."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Pistoia V."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Gambini C."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Pistorio A."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Deaglio S."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Cocco C."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Raffaghello L."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Cilli M."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Pezzolo A."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Marimpietri D."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/author | "Parodi F."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/pages | "1470-1486"xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/title | "Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/21403679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21403679 |
| http://purl.uniprot.org/citations/21403679 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21403679 |
| http://purl.uniprot.org/uniprot/#_F2Z381-mappedCitation-21403679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21403679 |
| http://purl.uniprot.org/uniprot/#_D3YHM4-mappedCitation-21403679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21403679 |
| http://purl.uniprot.org/uniprot/#_D5K9R7-mappedCitation-21403679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21403679 |