| http://purl.uniprot.org/citations/21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21407176 | http://www.w3.org/2000/01/rdf-schema#comment | "Fidelity of chromosome segregation is ensured by a tension-dependent error correction system that prevents stabilization of incorrect chromosome-microtubule attachments. Unattached or incorrectly attached chromosomes also activate the spindle assembly checkpoint, thus delaying mitotic exit until all chromosomes are bioriented. The Aurora B kinase is widely recognized as a component of error correction. Conversely, its role in the checkpoint is controversial. Here, we report an analysis of the role of Aurora B in the spindle checkpoint under conditions believed to uncouple the effects of Aurora B inhibition on the checkpoint from those on error correction. Partial inhibition of several checkpoint and kinetochore components, including Mps1 and Ndc80, strongly synergizes with inhibition of Aurora B activity and dramatically affects the ability of cells to arrest in mitosis in the presence of spindle poisons. Thus, Aurora B might contribute to spindle checkpoint signalling independently of error correction. Our results support a model in which Aurora B is at the apex of a signalling pyramid whose sensory apparatus promotes the concomitant activation of error correction and checkpoint signalling pathways."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2011.70"xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/author | "Musacchio A."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/author | "Ciliberto A."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/author | "Santaguida S."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/author | "Villa F."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/author | "Vernieri C."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/pages | "1508-1519"xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/title | "Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction."xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/21407176 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21407176 |
| http://purl.uniprot.org/citations/21407176 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21407176 |
| http://purl.uniprot.org/uniprot/#_P51955-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_Q12834-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_Q13257-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_O43684-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_O60566-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_O14965-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_P02662-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_P53350-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_Q5E9F8-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |
| http://purl.uniprot.org/uniprot/#_Q8TF76-mappedCitation-21407176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21407176 |