| http://purl.uniprot.org/citations/21410322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21410322 | http://www.w3.org/2000/01/rdf-schema#comment | "Reg family proteins such as Reg1 and islet neogenesis-associated protein (INGAP) have long been implicated in the growth and/or neogenesis of pancreatic islet cells. Recent reports further suggest similar roles to be played by new members such as Reg2, Reg3α, and Reg3β. We have studied their age-, isoform-, and tissue-specific expressions. RNA and protein were isolated from C57BL/6 mice aged 7, 30, and 90 days. Using real-time polymerase chain reaction, the levels of Reg gene expression in the pancreas were 20-600-fold higher than that in other tissues (≫duodenum>stomach>liver); gene expression of Reg2, Reg3α, and Reg3β was age dependent as it was hardly detectable at day 7, increased drastically at day 30, and significantly decreased at day 90; the levels of pancreatic proteins displayed similar age-dependent variations. Using dual-labeled immunofluorescence, Reg2, Reg3α, and Reg3β were abundantly expressed in most acinar cells of the pancreas, in contrast to INGAP which exhibited stepwise increases from day 7 to day 90 and colocalized with the α-cells. These new Reg genes were mainly expressed in the pancreas, with clear age-dependent and isoform-specific patterns."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.org/dc/terms/identifier | "doi:10.3109/08977194.2011.562866"xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Xiong X."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Liu J.L."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Siddique T."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/author | "Jacovetti C."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/pages | "72-81"xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/title | "Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3alpha, and Reg3beta genes."xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/21410322 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21410322 |
| http://purl.uniprot.org/citations/21410322 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21410322 |
| http://purl.uniprot.org/uniprot/#_P35230-mappedCitation-21410322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21410322 |
| http://purl.uniprot.org/uniprot/#_Q08731-mappedCitation-21410322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21410322 |
| http://purl.uniprot.org/uniprot/#_Q545J0-mappedCitation-21410322 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21410322 |
| http://purl.uniprot.org/uniprot/P35230 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21410322 |
| http://purl.uniprot.org/uniprot/Q08731 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21410322 |
| http://purl.uniprot.org/uniprot/Q545J0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21410322 |