| http://purl.uniprot.org/citations/21410323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21410323 | http://www.w3.org/2000/01/rdf-schema#comment | "The estrogen receptor (ER) is a primary target for breast cancer (BC) treatment. As BC progresses to estrogen-independent growth, the insulin-like growth factor-1 receptor (IGF-1R) and the ER interact in synergistic cross-talk mechanisms, which result in enhanced activation of both receptors' signaling cascades. Insulin-like growth factor-2 (IGF-2) is critical in BC progression and its actions are mediated by the IGF-1R. Our previous studies showed that IGF-2 regulates survival genes that protect the mitochondria and promote chemoresistance. In this study, we analyzed BC cells by subcellular fractionation, Western-Blot, qRT-PCR, and siRNA analysis. Our results demonstrate that IGF-2 activates ER-α and ER-β, and modulates their translocation to the nucleus, membrane organelles, and the mitochondria. IGF-2 actions are mediated by the IGF-1R and the insulin receptor. This novel mechanism of IGF-2 synergistic cross-talk signaling with ER-α and ER-β can promote estrogen-independent BC progression and provide new therapeutic targets for the treatment of BC patients."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.org/dc/terms/identifier | "doi:10.3109/08977194.2011.565003"xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/author | "Davis W."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/author | "Richardson A.E."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/author | "Brito C."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/author | "Hamilton N."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/author | "De Leon D."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/name | "Growth Factors"xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/pages | "82-93"xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/title | "Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-alpha and -beta via the IGF-1 and the insulin receptors in breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/21410323 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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