| http://purl.uniprot.org/citations/21411641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21411641 | http://www.w3.org/2000/01/rdf-schema#comment | "Injury and inflammation are potent regulators of adult neurogenesis. As the complement system forms a key immune pathway that may also exert critical functions in neural development and neurodegeneration, we asked whether complement receptors regulate neurogenesis. We discovered that complement receptor 2 (CR2), classically known as a coreceptor of the B-lymphocyte antigen receptor, is expressed in adult neural progenitor cells (NPCs) of the dentate gyrus. Two of its ligands, C3d and interferon-α (IFN-α), inhibited proliferation of wild-type NPCs but not NPCs derived from mice lacking Cr2 (Cr2(-/-)), indicating functional Cr2 expression. Young and old Cr2(-/-) mice exhibited prominent increases in basal neurogenesis compared with wild-type littermates, whereas intracerebral injection of C3d resulted in fewer proliferating neuroblasts in wild-type than in Cr2(-/-) mice. We conclude that Cr2 regulates hippocampal neurogenesis and propose that increased C3d and IFN-α production associated with brain injury or viral infections may inhibit neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3617-10.2011"xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Moriyama M."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Molina H."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Wyss-Coray T."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Fukuhara T."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Huber B.T."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Narasimhan R."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Britschgi M."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Holers M."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/author | "Villeda S."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/pages | "3981-3989"xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/title | "Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/21411641 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A1B0GS59-mappedCitation-21411641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411641 |
| http://purl.uniprot.org/uniprot/#_E9Q3S5-mappedCitation-21411641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411641 |