| http://purl.uniprot.org/citations/21411731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21411731 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophage migration inhibitory factor (MIF) promotes leukocyte recruitment to sites of inflammation. However, whether this stems from a direct effect on leukocyte migration is unknown. Furthermore, the role of the MIF-binding protein CD74 in this response has not been investigated. Therefore, the aim of this study was to examine the contributions of MIF and CD74 to chemokine-induced macrophage recruitment. Intravital microscopy studies demonstrated that CCL2-induced leukocyte adhesion and transmigration were reduced in MIF(-/-) and CD74(-/-) mice. MIF(-/-) and CD74(-/-) macrophages also exhibited reduced chemotaxis in vitro, although CD74(-/-) macrophages showed increased chemokinesis. Reduced CCL2-induced migration was associated with attenuated MAPK phosphorylation, RhoA GTPase activity, and actin polymerization in MIF(-/-) and CD74(-/-) macrophages. Furthermore, in MIF(-/-) macrophages, MAPK phosphatase-1 was expressed at elevated levels, providing a potential mechanism for the reduction in MAPK phosphorylation in MIF-deficient cells. No increase in MAPK phosphatase-1 expression was observed in CD74(-/-) macrophages. In in vivo experiments assessing the link between MIF and CD74, combined administration of MIF and CCL2 increased leukocyte adhesion in both MIF(-/-) and CD74(-/-) mice, showing that CD74 was not required for this MIF-induced response. Additionally, although leukocyte recruitment induced by administration of MIF alone was reduced in CD74(-/-) mice, consistent with a role for CD74 in leukocyte recruitment induced by MIF, MIF-treated CD74(-/-) mice displayed residual leukocyte recruitment. These data demonstrate that MIF and CD74 play previously unappreciated roles in CCL2-induced macrophage adhesion and migration, and they indicate that MIF and CD74 mediate this effect via both common and independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1003713"xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Hickey M.J."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Fan H."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Hall P."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Bucala R."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Fingerle-Rowson G."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Santos L.L."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Morand E.F."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/author | "Gregory J.L."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/pages | "4915-4924"xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/title | "Macrophage migration inhibitory factor and CD74 regulate macrophage chemotactic responses via MAPK and Rho GTPase."xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/21411731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21411731 |
| http://purl.uniprot.org/citations/21411731 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21411731 |
| http://purl.uniprot.org/uniprot/#_P34884-mappedCitation-21411731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411731 |
| http://purl.uniprot.org/uniprot/#_Q3U4Q8-mappedCitation-21411731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411731 |
| http://purl.uniprot.org/uniprot/#_P04441-mappedCitation-21411731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411731 |
| http://purl.uniprot.org/uniprot/#_Q545Y5-mappedCitation-21411731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411731 |
| http://purl.uniprot.org/uniprot/#_Q545F0-mappedCitation-21411731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21411731 |
| http://purl.uniprot.org/uniprot/Q545Y5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21411731 |
| http://purl.uniprot.org/uniprot/P04441 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21411731 |